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In clinical trials, the incidence of creatine phosphokinase CPK 10 x ULN was 0, anvarol before and after. Risk for skeletal muscle toxicity increases with higher doses of statin, advanced age 65 , hypothyroidism, renal impairment, and depending on the statin used, concomitant use of other drugs. In post-marketing experience with ZETIA, cases of myopathy and rhabdomyolysis have been reported. Most patients who developed rhabdomyolysis were taking a statin prior to initiating ZETIA.
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